| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Roxana | A | Carlisle | Lohman | Daugherty | Eads | 2:01.33 | |
| 2 | Belleville (Althoff Catholic | A | Thorpe | Reyes-Cruz | Distler | Distler | 1:58.59 | |
| 3 | Rochester | A | Bruzonlobaton | Kerwin | Johnson | Tom | 1:57.19 | |
| 4 | Springfield (Lanphier) | A | Washington | Jackson | Davis | Rynsburger | 1:54.77 | |
| 5 | Jerseyville (Jersey) | A | Yamnitz | Peterbaugh | Allen | Trexler | 1:56.56 | |
| 6 | Wood River (East Alton-W.R.) | A | Minner | Skinner | Sanders | LeGette | 1:57.34 | |
| 7 | Greenville | A | Bellegante | Rohr | DeBlois | Neely | DNS |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Highland | A | Henschen | Pollard | Maas | Thomas | 1:52.75 | |
| 2 | Troy (Triad) | A | DiRosa | Nadler | Schardan | Witham | 1:50.02 | |
| 3 | Springfield (Southeast) | A | Howze | Rice | Jackson | Hobson | 1:47.40 | |
| 4 | East St. Louis (Sr.) | A | Jones | Glenn | Graham | Lampley | 1:44.09 | |
| 5 | Springfield (Sacred Heart-Gr | A | Bartletti | Paul | Paul | Redpath | 1:46.45 | |
| 6 | Cahokia (H.S.) | A | Ransom | Suggs | Beckwith | Pomerlee | 1:48.34 | |
| 7 | Taylorville | A | Althoff | Odam | Vail | Lowis | 1:51.19 | |
| 8 | Breese (Central) | A | Tebbe | Luth | Detmer | Taylor | 1:54.45 |