| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 2 | Springfield (Sacred Heart-Griffin) | A | Hanauer | Whyte | Boesdorfer | Sanchez | 3:53.53 | |
| 3 | Roxana | A | Wells | McBride | Osmoe | Doyle | 3:45.24 | |
| 4 | Jacksonville (H.S.) | A | Finn | Armstrong | Armstrong | Reed | DNS | |
| 5 | Rochester | A | Huet | Hobson | Trello | Mrozowski | 3:37.75 | |
| 6 | Wood River (East Alton-W.R.) | A | Wilcutt | Gould | Burgess Jr | Lane | DQ | |
| 7 | Greenville | A | Redding | File | Wilson | Battaglia | 3:58.64 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Troy (Triad) | A | Yohannes | Warren | Dempsey | Venhaus | 3:34.91 | |
| 2 | Breese (Central) | A | Hunt | Revermann | Buschmann | Shubert | 3:32.34 | |
| 3 | Springfield (Southeast) | A | Day | Doss | Edwards | Turner | 3:26.89 | |
| 4 | East St. Louis (Sr.) | A | Cross | Ivy | Montgomery | Stepney | 3:19.61 | |
| 5 | Cahokia (H.S.) | A | Lyons | Pennington | Raiford | Deloach | 3:25.62 | |
| 6 | Springfield (Lanphier) | A | Robinson | Smith | Holmes | Harris | 3:28.96 | |
| 7 | Bethalto (Civic Memorial) | A | Eldridge | Naugle | Gares | Wooten | 3:34.40 | |
| 8 | Highland | A | Basden | Steinbeck | Miller | Fridley | 3:36.24 |