| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 2 | Triad | A | Martens | Dudley | Werner | Goolsby | 4:12.00 | |
| 3 | Granite City | A | Dean | Clutts | Brokaw | Rodgers-Parott | 3:55.00 | |
| 4 | O'Fallon | A | Ross | Sheppard | Turner | Fisher | 3:46.00 | |
| 5 | Collinsville | A | Brock | Hendrickson | Strong | Mosby | 3:55.00 | |
| 6 | Belleville East | B | Perkins | Owens | Cotton | Schnarre | 3:57.00 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Edwardsville | B | Paty | Lueking | Hoeferlin | Davis | 3:43.24 | |
| 2 | Belleville West | B | Brown | Weston | Issa | Goodrich | 3:40.00 | |
| 3 | Belleville West | A | Williams | Perry | Sutton | Mcclean | DNS | |
| 4 | Cahokia | A | Pennington | Raiford | Thomas | Taylor | 3:31.00 | |
| 5 | Alton | A | White | Macias | McAfoos | Whitfield | 3:33.57 | |
| 6 | Belleville East | A | Wright | Mitchell | Jones | Pete | 3:36.00 | |
| 7 | Edwardsville | A | Arendell | Bruhn | Kitchen | Gilmor | 3:42.24 | |
| 8 | Alton | B | Rounds | Parker | Holeman | Johnson | 3:45.00 |