| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 2 | Belleville East | A | Deere | Bacon | Peppers | Armour | 4:19.74 |
| 3 | Edwardsville | A | Hockett | Hockett | Knoyle | Welsh | 4:15.82 |
| 4 | Belleville West | A | King | Dunn | Lewis | Sparks | 4:14.32 |
| 5 | East St. Louis | A | Hawkins | Glenn | Graham | Box | 4:15.00 |
| 6 | O'Fallon | A | Daniels | Brown | Perry-Anderson | Schieppe | 4:17.00 |
| 7 | Collinsville | A | Dawson | Harris | Parish | Jimenez | DNS |