| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 3 | Mascoutah | A | Sutliff | Phillips | Beyer | Feldt | 1:46.00 |
| 4 | Granite City | A | Poston | Ivy | Dowell | DNS | |
| 5 | Collinsville | A | Edwards | Jones | Epps | Nelson | 1:44.56 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 2 | O'Fallon | A | Doss | Suggs | Joiner | Brady | 1:37.00 |
| 3 | Alton | A | Ballinger III | Telford | Billups | Hardin | 1:35.00 |
| 4 | Belleville East | A | Oluwatimilehin | Foster | Bennett | Mcgill | 1:34.00 |
| 5 | Belleville West | A | Dowell | Collins | Abram | Nicholson | 1:34.00 |
| 6 | Edwardsville | A | Bush | Brnfre | Larson | Schmidt | 1:36.55 |
| 7 | Rockwood Summit | A | Wallace | Zerr | Lackey | Pitts | 1:38.41 |