| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 2 | Civic Memorial | A | Silva | Burnett | Atteberry | Fonrodona | 1:39.50 | |
| 3 | Murphysboro | A | Huff-Baker | Kellum | Kellum | Beard | 1:38.48 | |
| 4 | Quincy | A | Moore | Altman | Herring | Homan | 1:35.09 | |
| 5 | Rochester | A | Hobson | Slott | Pletsch | Olson | 1:36.00 | |
| 6 | Springfield | A | Kaisner | Walden | Wilson | Thurman | 1:38.85 | |
| 7 | Columbia | A | Foxx | Frentzel | Donavan | Buelteman | 1:42.42 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Freeburg | A | Merz | Jarvis | Zhu | Thompson | 1:34.16 | |
| 2 | Collinsville | A | Munoz | Yarbough | Strong | Patterson | 1:33.99 | |
| 3 | Carbondale | A | Kebinang | Robbins | Burnside | Gleason | 1:33.54 | 37th Annual Marion Boys Track Relays |
| 4 | Alton | A | Singleton | Harris | White | Elliott-Barnes | 1:31.06 | |
| 5 | Belleville East | A | Moise | Wright | Fulton-Wilson | Dewalt | 1:31.10 | |
| 6 | Lanphier | A | Holmes | Harris | Robinson | Hall-Burton | 1:33.76 | |
| 7 | Waterloo | A | Pete | Brewer | Huebner | Kettler | 1:34.07 | |
| 8 | Roxana | A | Wells | Wieneke | Osmoe | McBride | DNS |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 1 | Belleville West | A | Fountian | Lockwood | Smith-Johnson | Clark | 1:30.50 | |
| 2 | Mascoutah | A | Reed | Holcomb | Stoltz | Feldt | 1:30.18 | |
| 3 | Cahokia | A | Baxtron | Deloach | Taylor | Pennington | 1:29.68 | |
| 4 | St. Mary's (St. Louis) | A | Strong | Washington | Hendricks | Roberts | DNS | |
| 5 | Edwardsville | A | Brnfre | Lakatos | Wilson | Lane | 1:29.62 | |
| 6 | East St. Louis | A | Wren | Cross | Buchanon | Smith | 1:30.00 | |
| 7 | O'Fallon | A | Green | Clark | Doss | Faver | 1:30.48 | |
| 8 | Glenwood | A | Marcordes | Downen | Sgro | Saunders | 1:30.53 |