| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 3 | Salem | A | See | Huggins | Patterson | Ettress | 1:52.00 |
| 4 | Civic Memorial | A | Flanigan | Flanagan | Walters | Gares | 1:45.50 |
| 5 | Breese Central | A | MacDonald | Becker | Davis | Jansen | 1:48.00 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Triad | A | Hard | Martens | Davis | Werner | 1:38.00 |
| 2 | Highland | A | Wallace | Fridley | Miller | Nimmo | 1:36.55 |
| 3 | Mascoutah | A | Creamer | Stoltz | Holcomb | Reed | 1:35.64 |
| 4 | Edwardsville | A | Word | Lyles | Wahl | Stemmons | 1:35.34 |
| 5 | Collinsville | A | Patterson | Shelton | Strong | Munoz | 1:35.50 |
| 6 | Madison | A | Rogers | Brown | Collins | Hines III | 1:36.00 |
| 7 | O'Fallon | A | Fisher | Pasley | Patterson | Burks | 1:38.00 |
| 8 | Effingham | A | Ring | Lybarger | Wendling | Latham | 1:40.00 |