| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 4 | Father McGivney Catholic | A | Ahring | Shearer | Kohlberg | Biermann | 4:10.00 |
| 5 | Staunton | A | Oller | Ogata | Matesa | Buffington | 4:00.00 |
| 6 | East Alton-Wood River | A | Loffleman | Wilcutt | Burgess Jr | Gould | 4:00.00 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 3 | Althoff Catholic | A | Schallert | Schallert | Cole | Clemons | 4:00.00 |
| 4 | Granite City | A | Dean | Clutts | Lyons | Davis | 3:58.00 |
| 5 | Jersey | A | Burch | Jones | Judkins | Loges | 3:57.00 |
| 6 | Litchfield | A | Powell | Jones | Maguire | Grammer | 3:57.67 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Red Bud | A | Schluter | Wagner | Luthy | Baldwin | 3:54.40 |
| 2 | Rochester | A | Bruce | Mrozowski | Olson | Gustafson | 3:54.00 |
| 3 | Highland | A | Fridley | Steinbeck | Smart | Smith | 3:52.72 |
| 4 | Hillsboro | A | Wells | Cunningham | Hubbart | Fowler | 3:52.00 |
| 5 | Roxana | A | McBride | Schmidt | Wells | Osmoe | 3:50.00 |
| 6 | Quincy | A | McClelland | Lyssy | Hess | Homan | 3:50.00 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Freeburg | A | Duffie | Pluff | Banks | Frech | 3:47.34 |
| 2 | Civic Memorial | A | Eldridge | Naugle | Dutton | Collman | 3:47.00 |
| 3 | Mascoutah | A | Owens | Feldt | Fuess | Killian | 3:46.74 |
| 4 | Glenwood | A | Keppler | Canedy | Maughan | McCubbin | 3:45.00 |
| 5 | Waterloo | A | Brewer | Pete | Huebner | Kettler | 3:36.00 |
| 6 | Carlinville | A | Sproull | Dunn | Roper | Rouse | 3:45.00 |