| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Collinsville | A | Jeremias | Parish | Gilmore | Kohler | 4:40.00 |
| 2 | Alton | A | Miller | Stark | Ingram | Raglin | DNS |
| 3 | O'Fallon | A | Daniels | Perry-Anderson | Pelly | Tart | 4:06.70 |
| 4 | Belleville East | A | Quarles | Peppers | Peppers | Armour | 4:03.15 |
| 5 | Belleville West | A | Williams | Robinson | Hall | Sparks | 4:03.80 |
| 6 | Edwardsville | A | Bell | Hockett | Peel | Flannery | 4:07.72 |
| 7 | East St. Louis | A | Hawkins | Glenn | Graham | Lampley | 4:08.00 |