| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | East Alton-Wood River | A | Franklin | Jones | Lane | Gould | 1:55.00 |
| 2 | Granite City | A | Rodgers | Davis | Lyons | Dowell | 1:49.00 |
| 3 | Southeast (Springfield) | A | Murphy | Jerome | Berry | Solomon | 1:45.25 |
| 4 | Civic Memorial | A | Fonrodona | Wooten | Silva | Burnett | 1:45.00 |
| 5 | Staunton | A | Trettenero | Rantanen | Kapp | Matesa | 1:44.00 |
| 6 | Highland | A | Schonhardt | Steinbeck | Ward | Lewis | 1:44.66 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Collinsville | A | Brown | Gordon | Richardson | Nichols | 1:43.69 |
| 2 | Pleasant Plains | A | Skelton | Donnelly | Conn | Glisson | 1:43.00 |
| 3 | Lanphier | A | Harris | Bass | Holmes | Horne | 1:42.97 |
| 4 | Jersey | A | Borkowski | Loges | Talley | Jones | 1:42.00 |
| 5 | Salem | A | Ettress | Johnson | Pappas | Mayes | DNS |
| 6 | Limestone | A | Powell | Mullens | Nunez | Ochoa | 1:41.50 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Belleville East | A | Liddell | Fulton-Wilson | Mcgill | Howard | 1:41.50 |
| 2 | Triad | A | Randoll | Qualls | Friederich | Willis | 1:40.00 |
| 3 | Mascoutah | A | Mack | Phillips | Owens | Allen | 1:39.82 |
| 4 | Centralia | A | Brooks | Coriell | Smith | Ross | 1:39.08 |
| 5 | Columbia | A | Kronk | Scott | Komen | Donavan | 1:38.50 |
| 6 | North Mac | A | Hogan | Corey | Graves | Brown | 1:38.90 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | New Berlin | A | Crews | Williams | Tirey | Wellman | 1:38.00 |
| 2 | St. Teresa | A | Williams | Harper | Brilley | Walker | 1:36.45 |
| 3 | Alton | A | Elliot-Barnes | Pinnix | Taul | McClain | 1:35.00 |
| 4 | Shelbyville | A | Fisher | Smith | Foil | Kull | 1:35.00 |
| 5 | Rochester | A | Huet | Olson | Powers | Trello | 1:33.00 |
| 6 | East St. Louis | A | Wren | Taylor | Cross | Montgomery | 1:34.00 |