| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 3 | St. Teresa | A | Deetz | Auburn | Babcock | Sutton | NT |
| 4 | Centralia | A | Dahlquist | Bratton | Mayer | Morgan | NT |
| 5 | Mascoutah | A | Feldt | Carr | O'Leary | Drain | 4:12.00 |
| 6 | Civic Memorial | A | Walters | Zampieri | LeBlanc | Kearby | 4:15.00 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Jersey | A | Burch | Deist | Judkins | Little | 4:10.00 |
| 2 | Triad | A | Dempsey | Harmon | Dudley | Werner | 4:07.00 |
| 3 | Pleasant Plains | A | Clark | Crater | Merriman | Payne | 4:05.00 |
| 4 | North Mac | A | Graves | Richardson | Hipsher | Hundertmark | 4:05.00 |
| 5 | Belleville East | A | Wright | Moise | Ellis | Fuller | 4:00.00 |
| 6 | Salem | A | Shober | Malan | Purintun | Patterson | 4:00.00 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Staunton | A | Mathis | Smith | Haas | Myers | 4:00.00 |
| 2 | Southeast (Springfield) | A | Hutchinson | Gardner | Dibello | Kanu | 3:59.98 |
| 3 | Granite City | A | Dean | Martin | Clutts | Lyons | DQ |
| 4 | Lanphier | A | Jackson | Pitts | Brown-Sanchez | Eades | 3:56.67 |
| 5 | Highland | A | Fridley | Smart | Brock | Steinbeck | 3:52.40 |
| 6 | Limestone | A | Smallwood | Trammell | Silomba | Manley | 3:52.50 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | Alton | A | Cowan | Rounds | Parker | Hoover | 3:50.00 |
| 2 | Rochester | A | Weiskopf | Bridge | Clarke | Veach | 3:49.00 |
| 3 | Greenville | A | Bohn | Rodgers | Boyce | Fassold | DNS |
| 4 | Collinsville | A | Patterson | Nabors | Dowell | Priest | 3:43.00 |
| 5 | Columbia | A | Fromme | Steele | Curtis | Range | 3:39.50 |
| 6 | East St. Louis | A | Baker | Mosley | Smith | Coleman | 3:40.00 |